Department of Urology, Santa Casa de Porto Alegre, Brazil.
PURPOSE: We determined the efficacy of atropine sulfate combined with
papaverine hydrochloride, prostaglandin E1 and phentolamine mesylate in the
pharmacological erection test. MATERIALS AND METHODS: A total of 230
consecutive patients with erectile dysfunction was randomized for
pharmacological erection test and received an intracorporeal combination of
50 mg. papaverine hydrochloride, 10 micrograms. prostaglandin E1, 0.2 mg.
phentolamine mesylate and 0.075 mg. of atropine sulfate (group 1), or the
same combination without atropine sulfate (group 2). Erectile response was
evaluated subjectively and by intracorporeal pressure measurement. RESULTS:
In group 1, 40 patients (35.1%) showed only tumescence, and 22 (19.3%) had
poor erection. In group 2, 45 patients (39.5%) had tumescence and 17 (14.9%)
poor erection. In both groups 52 patients (45.6%) had rigid erection. There
was no statistically significant difference regarding erectile response and
intracorporeal pressure. CONCLUSIONS: The addition of atropine sulfate did
not improve results of the pharmacological erection test when combined with
50 mg. papverine hydrochloride, 10 micrograms, prostaglandin E1, and 0.2 mg.
phentolamine mesylate.
Post by 3fishesDear Lmac,
Thanks for your reply. So far nobody reply on why Atropine is added to
Trimix to make it Quadmix. There is lots of compounding pharmacist
offer this mixture. I understand when atropne eyes drop 1% instill on
eyes, it will dilate pupil for days, may be even a week. Just try to
understand the reason on this addition benefit ? Further dilation of
blood vessel ? or inhibit of parasym Nerves system so Sym Nerve system
take over ?Some study show, it work on some patient who fail with
Trimix. Any educated guess ?
Thanks
Ralph.
Post by LMacPost by 3fishesDear Sir,
Have someone try Quad-mix ? which is Trimix with added atropine. Is
Quad-mix better than Trimix ? How is Atropine work in this situation ?
and on what concentration ? Feeling ? Just read this one on a
compounding pharmacist webtsite.
Strange! Only injections of Atropine I've had were during nerve gas
training in the military. Caused a very dry mouth and some vision
disturbances. It's also used to arrest an allergic attack from an
inoculation. No clue as to what it would do inside one's dick. Just
bought a vial so won't see my pharmacist right away but will ask her in
a couple of months should no answer appear here.
Post by 3fishesOpinion on 31Gauge needle in 8mm vs 31G in 12.5mm( 1/2inch) needle -
will 8 mm increase the chance of missing the depth on fat individual ?
I don't have a lot of flaccid girth and usually have over 4mm of needle
length left when the force eases as the needle punctures into the
cavernosa. So, I have a lot of confidence in using 31gx8mm--although I
never had a problem with 12.5's. Assuming you are now using 12.5mm, do
a slow puncture on your next shot and estimate the thickness of skin,
fat, sheath, etc.
Post by 3fishesIf fail with 20mcg on Caverject at home, should increase dosage on
Caverject or switch to Trimix on my next visit. Caverject is too
expensive. I appreicate your support. Thanks.
As usual, no docs here. Work this one out with your own Uro.
...LMac